The idea in brief : Spring batch as a model for CRISPR Cas9

The analogy between  Spring Batch and the CRISPR-Cas9  system   is an innovative conceptual model proposed notably by  Wadï Mami on ResearchGateThis framework transposes the steps of software engineering to molecular biology to structure the understanding of the genome editing process. 

Component matching
The architecture of Spring Batch (Read-Process-Write) aligns with the key phases of CRISPR-Cas9:
  • ItemReader / Genome Identification  : In Spring Batch, this  Reader extracts the data. In biology, this corresponds to exploring and identifying the target DNA sequence within the genome.
  • ItemProcessor / RNA Design and Binding  : This  Processor transforms the data. Here, it models the design of the guide RNA (gRNA) and the binding of the Cas9 enzyme to the target. Algorithms such as  Karp-Rabin  or  Levenshtein distance  are proposed to simulate this motif search.
  • ItemWriter / Cut and Repair  : The  Writer changes persist. This represents the "scissors" action of Cas9 (cleavage) and the repair of DNA by the cell, which effectively "writes" the new genetic information. 

-- Minds, like parachutes, function best when open. ,,,

             (o o)

/ --------oOO--(_)--OOo----------\

| Wadï Mami didipostman

| Github:  https://www.github.com/didipostman

| e-mail:  wmami@steg.com.tn  /  didipostman77@gmail.com

| ----------------------------------------/

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