L'idée en bref Spring batch as a model for Crispr Cas9

 L'analogie entre Spring Batch et le système CRISPR-Cas9 est un modèle conceptuel innovant proposé notamment par Wadï Mami sur ResearchGate. Ce cadre transpose les étapes du génie logiciel à la biologie moléculaire pour structurer la compréhension du processus d'édition génomique.

Correspondance des composants
L'architecture de Spring Batch (Lecture-Traitement-Écriture) s'aligne sur les phases clés de CRISPR-Cas9 :
  • ItemReader / Identification du génome : Dans Spring Batch, le Reader extrait les données. En biologie, cela correspond à l'exploration et à l'identification de la séquence d'ADN cible au sein du génome.
  • ItemProcessor / Design de l'ARNg et Liaison : Le Processor transforme la donnée. Ici, il modélise la conception de l'ARN guide (ARNg) et la liaison de l'enzyme Cas9 à la cible. Des algorithmes comme Karp-Rabin ou la distance de Levenshtein sont proposés pour simuler cette recherche de motifs.
  • ItemWriter / Coupure et Réparation : Le Writer persiste les changements. Cela représente l'action de "ciseaux" de Cas9 (clivage) et la réparation de l'ADN par la cellule, qui "écrit" effectivement la nouvelle information génétique.

-- Minds, like parachutes, function best when open. ,,,

             (o o)

/ --------oOO--(_)--OOo--------------------\

| Wadï Mami didipostman

| Github : https://www.github.com/didipostman

| e-mail : wmami@steg.com.tn / didipostman77@gmail.com

| ----------------------------------------/

 

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